This formula is an Optimal methylation formula with activating co-factor created by Kendal Stewart, MD to support the methylation pathway and provide adequate Folinic Acid and methyl folate (5-MTHF).
Methyl Folate Plus is designed to be used in conjunction with our Methylation Complete Dissolvable Tablets OR Neuro-Immune Stabilizer Topical Cream that provides the activating co-factors to deliver the additional tetrahydrofolate to support issues associated with methylation deficiencies.. Most often poor methylators will need additional methyl folate.
The addition of Niacinamide helps support the mitochondria and supports as a cofactor for the delivery of the other ingredients in Methyl Folate Plus.
The typical indications for this product include but are not limited to:
- * Presence of Folate Receptor Autoantibodies
- *Homozygous (2 copies) MTHFR polymorphism
- *Development (ages 8-20)
- *Slow recovery from major neurological injuries
- *Moderate to severe autism spectrum issues
- *Poor recovery from traumatic injury
Folinic acid (also known as Leucovorin) is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid.
5-MTHF (L-Methyl tetrahydrofolate) is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. Folate benefits cardiovascular health and nervous system function. Ordinary folic acid supplements may not deliver the full spectrum of effects. This is due to the fact that once ingested, not everyone converts the usual folic acid supplements to their biologically active form called 5-methyltetrahydrofolate (5-MTHF). Methyl Folate Plus provides 5-MTHF in its active form. Recent studies have shown that a significant portion of the population have genetic enzyme deficiencies which prevent the conversion by methylation of folate to 5-MTHF.
5-MTHF has been shown to be up to seven times more bioavailable than regular folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active. 5-MTHF is able to cross the blood-brain barrier to enhance brain synthesis of acetylcholine the neurotransmitter associated with memory, which is especially important for people with cognitive difficulties and neuro-immune syndromes.
Frequently asked question: Is 5-MTHF the same as L-Methylfolate?
It is. We use two types of MTHF, one stabilized with calcium and one stabilized with glucosamine (non-shellfish-derived). Both are synonymous with L-Methylfolate.
Special Considerations: People with MTHFR & FLOR SNPs benefit greatly from taking methylfolate. Always take Methyl B12 with methylfolate, as it is a needed cofactor in methylation.
Niacinamide does not cause flushing at any dose. However, it is readily converted to an enzyme called NADH that is needed for metabolism and energy production to support mitochondrial health. Unlike other vitamins, the body is able to make its own niacinamide using tryptophan as the raw material. Tryptophan is an amino acid the body also uses to make serotonin, a critical neurotransmitter for moods, sometimes referred to as the Òhappy brain chemical.Ó Since tryptophan is often in short supply in the body, taking niacinamide can help spare it and make more available for serotonin production. As a result, niacinamide has complex and supportive interactions with body and brain function as well as a wide range of benefits.
Vitamin B2 (Riboflavin-5-Phosphate) Riboflavin is critical for normal growth and repair. It is needed to facilitate normal reproduction, cell growth and repair, and development of tissues. The body utilizes vitamin B2 to keep tissue health and to help accelerate healing of injuries. Riboflavin acts to help the immune system to function properly by reinforcing the body's reserve of antibodies which guard against infection.
Along with other B Vitamins, Vitamin B2 helps protect the nervous system. It could be an essential component for optimal health.*
Directions: 1 capsule twice daily or as directed by your healthcare professional.
Best results provided is used along with one of our Methylation Support products.
Other Ingredients: rice flour, ascorbic palmitate, silicon dioxide, HPMC (vegetable capsule)
- Orders that are in stock are dispatched daily at 2pm Monday – Friday.
- Orders placed before 2pm Monday to Friday will be dispatched the same day.
- Orders placed after 2pm Monday to Friday will be dispatched the next working day.
- As such, orders placed after 2pm Friday will be dispatched the following Monday.
- Orders will not be dispatched on Bank Holidays or weekends.
For Standard Domestic Orders: We use Royal Mail’s Tracked 48hr delivery service as standard. Royal Mail state a delivery guideline of 1-2 working days for this service, however during busier periods (such as Christmas) this may not always be possible. If your order has not arrived after 2 working days from the date of dispatch please contact us. We have tracking numbers for this service and will be able to assist you in locating your order.
For Expedited Domestic Orders (Next-Day Delivery): Provided that we have received your order by 2pm, we will process and dispatch your order the same day using Royal Mail’s Tracked 24hr delivery service. This service aims to deliver your parcel within 24hrs of the dispatch time – in some instances this may not be possible and delivery may fall within a 48hr period. If you have not received your order after 1 day from the dispatch date please contact us. This is a tracked and insured service and we will be able to assist you in locating your order.
For Standard International Orders: We use Royal Mail International Track (+ Sign), dependent on what the destination country accepts. Royal Mail state a 3-5 working day delivery guideline for this service within Europe, and a 5-7 working day guideline worldwide. However, we have found this is rarely the case outside of major cities, especially during busier periods (such as Christmas) this may not always be possible. This is a tracked and insured service, please contact us if you have not received your delivery within the above stated time-frames and we will assist you in locating your order.
For Expedited International Orders: We are able to offer expedited international shipping worldwide respected couriers. We can use DHL or another courier of your choice, but we are likely to get the best deal from DHL. Please feel free to use the 'Contact Us' form to ask for a DHL quote for your order.
We are able to offer expedited delivery worldwide using various couriers; this is something that we will examine on a case-by-case basis. Please email us and we will investigate your delivery options and let you know what is possible.
If you have selected a shipping method that does not include tracking/insurance then you accept and agree that in the instance that the parcel is lost or delayed, you will not be entitled to a refund or a replacement product, as we will be unable to make a claim for the loss.
We retain proof of postage at all times and reserve the right to use a different shipping method than you have selected in order to give your order added security in certain circumstances (e.g. for extremely high value orders we may upgrade to Courier delivery). In the majority of situations we will respect the customers chosen shipping method. We retain proof of postage for 180 days. After this time it may not be possible to retrieve your proof of postage.