(Advanced Formula Protease) is a combination of three different enzymes that break down protein. These enzymes are isolated and purified from fungal plant sources. The combination of these specific enzymes allows much more efficient means of quickly and thoroughly breaking down (hydrolyzing) proteins to smaller components.
The enzymes in AFP Peptizyde work only on food proteins, not carbohydrates, fats, or other compounds, and do not interfere with medications or other supplements (unless they are also proteins, which is extremely unlikely). AFP Peptizyde may be used in combination with other enzyme products.
The enzyme dipeptidyl peptidase IV, or DPP IV, is able to break down and inactivate the exorphin peptide casomorphin, from dairy. However, for maximal protein breakdown, DPP IV is not useful alone, and should be combined with other proteases with different and less stringent peptide bond specificity.
For this reason, AFP Peptizyde contains two other fungal-derived proteases with high activity in acid conditions. These enzymes are present in AFP Peptizyde in high amounts for the purpose of quickly hydrolyzing (breaking down) proteins while the food is still in the stomach.
The ability of AFP Peptizyde enzymes to withstand the low pH of the stomach and remain active under acidic conditions allows breakdown of casein and gluten prior to entrance into the small intestine. Casein and gluten, in the presence of pancreatic enzymes in the small intestine, can produce exorphin peptides that may be readily absorbed from the intestine (these peptides are not absorbed from the stomach).
AFP Peptizyde supplements the "normal" breakdown of casein, gluten, and other food proteins such that the exorphin peptides are not produced because the specific cleavage pattern to produce these peptides is altered.
AFP Peptizyde also contains only those enzymes needed for protein hydrolysis. No other enzymes have been added. This allows you to customize enzyme supplementation to your specific needs.
Another advantage to this approach is that less potential exists for intolerance reactions due to additional and perhaps unnecessary enzyme proteins. Also, by using only three enzyme blends in AFP Peptizyde, larger amounts of each enzyme can be added per capsule. This ensures that more hydrolysis of food protein can take place in the short time that food is in the stomach.
AFP Peptizyde is also different from other companies' products in that it has allowed many families to safely modify or even abandon the gluten-free, casein-free (GFCF) diet, thus allowing families more choice in foods available, better nutrition (by re-incorporating important protein sources back into the family diet), and much less stress and worry from fear of food reactions.
Appetite may increase as well as showing more interest in other types of foods. AFP Peptizyde may allow for re-introduction of dairy and wheat products to the diet without abnormal behaviors occurring. Benefits from AFP Peptizyde do vary with each individual and may be affected by other supplements and diet. Other supplements, especially vitamin and minerals, may be decreased in amount or frequency of dosing as more nutrition is derived from diet with enzymes.
AFP Peptizyde is recommended for high protein diets and athletic training; and dosing may be increased for those meals that are higher in meat protein.
Using AFP Peptizyde™ as an Alternative to the GFCF Diet
The procedure recommended by most parents who have successfully abandoned the GFCF diet (gluten free, casein free) using AFP Peptizyde is to use the enzymes while maintaining the diet for a period of at least 2 months. When challenging with foods known to be a problem, use small portions initially with 1 or 2 capsules of AFP Peptizyde. The intention is to provide more than enough AFP Peptizyde to counter the effects of casein/gluten.
If the challenge was successful, increasing the amount of food given may be attempted, keeping in mind that more AFP Peptizyde may be necessary to counter the increased size of the food challenge. For occasional use, up to 4 capsules may be given for infractions, any more than that will probably not provide any additional benefit.
Contraindications for Enzyme Supplementation
These enzymes should be used with care in cases of active stomach or duodenal ulcers, severe bowel inflammation (characterized by blood in stools), hemophilia and other bleeding disorders, or within a week of scheduled surgery. This product may not be appropriate for those with known allergies to Aspergillus enzyme proteins, though non-specific mold allergies do not necessarily preclude use of fungal enzymes. Consult your medical doctor for further advice, and err on the side of caution. Those with known anaphylactic allergic reactions to fungal proteins should NOT ingest fungal-derived enzymes.
No upper limit has been established for enzyme dosing, and animal studies with similar enzymes found no toxicity at dosing as high as 2000 milligrams per kilogram of body weight per day for 90 days. Most find using 1 to 2 AFP Peptizyde capsules per meal adequate, and most likely no further benefits will occur with higher dosing, though more may be given for the infrequent and large food challenges. Each person is different so we encourage some experimentation to find the dose that best helps each person.
Frequently Asked Questions
If the capsule is opened and contents put on food or in drink, will the proteases hurt the mouth/throat?
The proteases should not be harmful if taken without the capsule. Some irritation may occur if the enzyme remains on the cheeks or gums due to a debriding action on the layer of dead skin cells. We recommend drinking or eating after taking the enzymes to clear the mouth of the enzymes, or brushing teeth, gargling, etc.
Will AFP-Peptizyde help those with Celiac Disease?
We make no claims for enzymes helping any disease condition. Celiac disease is very serious and those with the disease should stay on the doctor-advised gluten-free diet. Taking the enzymes while maintaining a gluten-free diet should do no harm.
Peptizyde® is a trademark of Houston Nutraceuticals, Inc.
AFP Peptizyde capsules
Serving Size: 1 Capsule Servings: 90
|Amount Per Serving||% Daily Value|
|Peptidase (source of DPP IV)||55,000 HUT||*|
|DPP IV activity||1,100 DPPU||*|
|Protease 4.5||25,000 HUT||*|
|Protease 6.0||25,000 HUT||*|
|*Daily Value Not Established|
Other Ingredients: Cellulose and Medium Chain Triglyceride powder (50% Medium Chain Triglyceride) .
Capsule is composed of vegetable cellulose and water.
No added sugar, starch, dairy, soy, wheat, yeast, gluten, nuts, artificial flavors, or animal derivatives.
- Orders that are in stock are dispatched daily at 2pm Monday – Friday.
- Orders placed before 2pm Monday to Friday will be dispatched the same day.
- Orders placed after 2pm Monday to Friday will be dispatched the next working day.
- As such, orders placed after 2pm Friday will be dispatched the following Monday.
- Orders will not be dispatched on Bank Holidays or weekends.
For Standard Domestic Orders: We use Royal Mail’s Tracked 48hr delivery service as standard. Royal Mail state a delivery guideline of 1-2 working days for this service, however during busier periods (such as Christmas) this may not always be possible. If your order has not arrived after 2 working days from the date of dispatch please contact us. We have tracking numbers for this service and will be able to assist you in locating your order.
For Expedited Domestic Orders (Next-Day Delivery): Provided that we have received your order by 2pm, we will process and dispatch your order the same day using Royal Mail’s Tracked 24hr delivery service. This service aims to deliver your parcel within 24hrs of the dispatch time – in some instances this may not be possible and delivery may fall within a 48hr period. If you have not received your order after 1 day from the dispatch date please contact us. This is a tracked and insured service and we will be able to assist you in locating your order.
For Standard International Orders: We use Royal Mail International Track (+ Sign), dependent on what the destination country accepts. Royal Mail state a 3-5 working day delivery guideline for this service within Europe, and a 5-7 working day guideline worldwide. However, we have found this is rarely the case outside of major cities, especially during busier periods (such as Christmas) this may not always be possible. This is a tracked and insured service, please contact us if you have not received your delivery within the above stated time-frames and we will assist you in locating your order.
For Expedited International Orders: We are able to offer expedited international shipping worldwide respected couriers. We can use DHL or another courier of your choice, but we are likely to get the best deal from DHL. Please feel free to use the 'Contact Us' form to ask for a DHL quote for your order.
We are able to offer expedited delivery worldwide using various couriers; this is something that we will examine on a case-by-case basis. Please email us and we will investigate your delivery options and let you know what is possible.
If you have selected a shipping method that does not include tracking/insurance then you accept and agree that in the instance that the parcel is lost or delayed, you will not be entitled to a refund or a replacement product, as we will be unable to make a claim for the loss.
We retain proof of postage at all times and reserve the right to use a different shipping method than you have selected in order to give your order added security in certain circumstances (e.g. for extremely high value orders we may upgrade to Courier delivery). In the majority of situations we will respect the customers chosen shipping method. We retain proof of postage for 180 days. After this time it may not be possible to retrieve your proof of postage.