Kirkman® offers 175 mg Trimethylglycine (TMG) in capsules with folinic acid and vitamin B-12. This is a hypoallergenic formulation, specially designed for individuals with special requirements and sensitivities.
Kirkman’s TMG is derived from beets, which is the commercially available source. TMG is dimethylglycine (DMG) with one more methyl group. The chemical structure of TMG is a glycine molecule holding onto three methyl groups. Like DMG, TMG is considered a "methyl donor" or “methyl bank." The additional methyl group makes TMG a more active methyl donor than DMG, which provides a benefit to some individuals. TMG can support the formation of methionine by methylating homocysteine. Some of this methionine eventually is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body, thus supporting mood and a feeling of well-being. As with DMG, TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylene tetrahydrofolate, an important component of many biochemical processes in the body including cellular perception and response.
Folic acid intake and levels in the body must be adequate for TMG to work biochemically. To be active in the body, folic acid needs to be reduced twice by folate reductase enzymes, then converted to tetrahydrofolate, after which a methyl group is added to the tetrahydrofolate. In some individuals, the use of natural folinic acid may be more beneficial than folic acid, because folinic acid already has attached four hydrogen atoms and one methyl group, thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis, which are so important in cell perception and response. For that reason, some doctors are recommending TMG with folinic acid instead of the folic acid form of folate.
Because folic acid can sometimes mask a vitamin B-12 deficiency, vitamin B-12 has also been included in this formulation. Furthermore, it is known that vitamin B-12 works synergistically with folic acid. The most active form of vitamin B-12 in folate chemistry is methylcobalamin, and Kirkman® utilizes this form of B-12 in this product, which may assist methionine metabolism, methylation, and folate chemistry.
Sugar, starch, soy, wheat, casein, gluten, milk, corn, preservatives, yeast, gelatin, flavorings, colorings, peanuts, tree nuts or fish.
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- Orders that are in stock are dispatched daily at 2pm Monday – Friday.
- Orders placed before 2pm Monday to Friday will be dispatched the same day.
- Orders placed after 2pm Monday to Friday will be dispatched the next working day.
- As such, orders placed after 2pm Friday will be dispatched the following Monday.
- Orders will not be dispatched on Bank Holidays or weekends.
For Standard Domestic Orders: We use Royal Mail’s Tracked 48hr delivery service as standard. Royal Mail state a delivery guideline of 1-2 working days for this service, however during busier periods (such as Christmas) this may not always be possible. If your order has not arrived after 2 working days from the date of dispatch please contact us. We have tracking numbers for this service and will be able to assist you in locating your order.
For Expedited Domestic Orders (Next-Day Delivery): Provided that we have received your order by 2pm, we will process and dispatch your order the same day using Royal Mail’s Tracked 24hr delivery service. This service aims to deliver your parcel within 24hrs of the dispatch time – in some instances this may not be possible and delivery may fall within a 48hr period. If you have not received your order after 1 day from the dispatch date please contact us. This is a tracked and insured service and we will be able to assist you in locating your order.
For Standard International Orders: We use Royal Mail International Track (+ Sign), dependent on what the destination country accepts. Royal Mail state a 3-5 working day delivery guideline for this service within Europe, and a 5-7 working day guideline worldwide. However, we have found this is rarely the case outside of major cities, especially during busier periods (such as Christmas) this may not always be possible. This is a tracked and insured service, please contact us if you have not received your delivery within the above stated time-frames and we will assist you in locating your order.
For Expedited International Orders: We are able to offer expedited international shipping worldwide respected couriers. We can use DHL or another courier of your choice, but we are likely to get the best deal from DHL. Please feel free to use the 'Contact Us' form to ask for a DHL quote for your order.
We are able to offer expedited delivery worldwide using various couriers; this is something that we will examine on a case-by-case basis. Please email us and we will investigate your delivery options and let you know what is possible.
If you have selected a shipping method that does not include tracking/insurance then you accept and agree that in the instance that the parcel is lost or delayed, you will not be entitled to a refund or a replacement product, as we will be unable to make a claim for the loss.
We retain proof of postage at all times and reserve the right to use a different shipping method than you have selected in order to give your order added security in certain circumstances (e.g. for extremely high value orders we may upgrade to Courier delivery). In the majority of situations we will respect the customers chosen shipping method. We retain proof of postage for 180 days. After this time it may not be possible to retrieve your proof of postage.