No Fenol by Houston Enzymes SCD Version 90 Capsules

No-Fenol was developed by Dr. Devin Houston in response to parent’s request for a product that would allow their children to eat fruits and vegetables without the problems thought to be associated with polyphenolic compounds. Initial response from many parents indicate that for many, No-Fenol does allow the addition of these foods to the diet without complications.

All plants contain some degree of phenolic compounds. The phenol structure itself is ubiquitous in nature, and is actually essential to many of life’s processes. Current thinking by many is that some subset of children on the PDD spectrum have difficulty in the processing of phenolic compounds, which may present as behavioral problems and physical symptoms such as red ears and cheeks, and dark circles under the eyes. While the basic mechanism behind this phenomenon is not well defined, it is thought that perhaps the phenolic compounds become "trapped" in some part of a metabolic cycle, presumbably involved with various detoxification pathways.

The research literature indicates that some phenolic compounds are modified by the addition of carbohydrate groups to their structures, which may inhibit their crossing into cells and being metabolized. The current hypothesis for why No-Fenol may help is through the ability of the enzymes in this product to remove the carbohydrate groups from the phenols, thus allowing normal processing by the detoxification pathways. There is no evidence that No-Fenol directly modifies phenolic structures. Indeed, the success of No-Fenol in allowing the addition of phenolic foods back into the diet of children with PDD may result in a re-evaluation of the basis of the phenol "problem".

Xylanase is the major component of No-Fenol, and is an enzyme used to breakdown the structural components of plant cell walls, which are primarily very complex carbohydrates. Xylanase is used in the juice industry to extract more juice from fruit pulp fibers. At least one reference indicates that polyphenolic compounds are actually increased by treatment with xylanase. Based on this reference and the fact that No-Fenol has allowed "phenol-sensitive" individuals to ingest phenolic foods, HNI now believes that the phenol issue is much more complex than previously thought, and may not be due so much to the presence of phenols as to the specific structure of these phenols.

Reported Benefits
Parental feedback indicates that No-Fenol allows many to eat some amount of phenolic foods without adverse effects on behavior or physical symptoms. A wide variation existed as to amounts and types of these foods that could be consumed. Parents report of improvements were strikingly similar to those noted with Peptizyde™, i.e., increased verbalization, more awareness, and more social behavior toward family members and peers. Those children with chronic constipation reported more frequent bowel movements. Some parents also reported that children could better tolerate food colorings and certain over the counter medications, such as cold medications and analgesic agents.

Reported Side Effects
Side effects were noted with initial use of No-Fenol and included hyperactivity, more frequent urination, and increased sweating. In most cases, these effects resolved over time or with adjustment of enzyme dose or decreased use of other supplements. Some parents noted a correlation between these effects and increased yeast "die-off", which can produce similar side effects. In some cases, stools were softer and less formed, which may be a result of the enzymes decreasing the viscosity of the intestinal contents, as noted in animal studies. This product may not be appropriate for those with known allergies to Aspergillus enzyme proteins, though non-specific mold allergies do not necessarily preclude use of fungal enzymes. Consult your medical doctor for further advice, and err on the side of caution. Those with known anaphylactic allergic reactions to fungal proteins should NOT ingest fungal-derived enzymes.

Contraindications for Enzyme Supplementation

Maximum dosing
No upper limit has been established for enzyme dosing, and animal studies found no toxicity at dosing as high as 80,000 FXU per kilogram of body weight per day for 13 weeks. No-Fenol is recommended primarily for those with known sensitivities to phenolic compounds. Recommended dosing is from ½ - 1 capsule with phenolic foods, but not necessarily with every meal. Some have found satisfactory results with once or twice per day dosing, indicating that optimal dosing may be dependent upon many factors.

Each capsule of No-Fenol contains:
Zyphenase™, a proprietary blend containing:
Xylanase........................32,000 XU
CereCalase......................1,500 MU
Cellulose

No-Fenol is free of rice, gluten, casein, soy, MSG, salicylates, sugar, and artificial colors.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, cure, treat, or prevent any disease.

Peptizyde™ and Zyphenase™ are trademarks of Houston Nutraceuticals, Inc.

CereCalase™ is a trademark of National Enzyme Company